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KMID : 0358619920260020129
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Korean Journal of Physiology
1992 Volume.26 No. 2 p.129 ~ p.136
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Effects of on the Contractility in the Antral Circular Muscle of Guinea-pig Stomach
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Kim Eui-Yong
Han Jin
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Abstract
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The effects of on spontaneous contraction, and the contractures induced by acetylcholine, 1mM caffeine were studied in order to elucidate diverse actions of on the mobilization related with contractility in the antral circular muscle of guinea pig stomach. inhibited the spontaneous contraction in a does dependent manner suppressed 60 mM induced contracture composed or a phasic and a tonic response and the increased tonic response by the increased external concentration. also suppressed acetylcholine induced contracture composed of repetitive phasic and a tonic component and the increased tonic response by the increased external concentration. Caffeine in the concentration of 1mM evoked contracture but suppressed the contracture. suppressed the amplitude of the tee contracture dose dependently and the amplitude of free contracture almost decreased to 20% of control amplitude in the concentration of . From the above results, it is suggested that may inhibit not only influx via voltage sensitive, receptor operated channel and Na/ca exchange but also intracellular release from the sarcoplasmic reticulum in the antral circular muscle of guinea pig stomach.
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KEYWORD
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, Contractility, Antral Circular Muscle, Guinea-pig stomach
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